# Latino

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $226,035

## Abstract

LATINO CORE - SUMMARY/ ABSTRACT
 Alzheimer’s disease and related dementias (ADRD) among U.S. Latinos are projected to increase over
nine-fold from 379,000 in 2012 to 3.5 million by 2060. Latinos represent 18% of the U.S. population and about
40% of the population of California. Latinos lag behind Whites and African-Americans in education and
healthcare insurance, and have cardiovascular, metabolic, and other disease burdens that exceed those of
Whites; however, Latino life-expectancy at birth surpasses that of Whites by over 3-years giving them greater
exposure to age-related risk of ADRD. Because of these factors, and cultural differences in reporting
behavioral, cognitive, and functional deficits, state-of-the-art clinical, neuropsychological, and neurological
procedures used to diagnose AD, that were largely developed and validated in relatively homogeneous, well-
educated, White, English-speaking populations, may not work effectively with monolingual Spanish-speaking
or Spanish-English bilingual older Latinos. Thus, there is a need for AD-related research in older Latinos to
overcome barriers to effective screening, assessment, diagnosis and treatment of early and preclinical
disease. There is also a need to better understand factors that impede or facilitate participation of elderly
Latinos (particularly Mexican-Americans) in AD-related research, including awareness of AD and its clinical
features, level of concern about the consequences of AD and burden of care, and willingness to participate in
research including procedures such as sampling of biomarkers, genetics, and autopsy. To address these
needs, the overall aims of the Latino Core are to: 1) conduct a linguistically- and culturally-appropriate memory
screening and evaluation program in predominantly Latino areas in San Diego to develop and maintain a
registry of well-characterized older Latino individuals who are interested in research and have agreed to be
contacted about on-going AD-related research studies; 2) conduct developmental research to refine and
evaluate linguistically- and culturally-appropriate clinical and cognitive assessment procedures to accurately
identify MCI and the transition to AD dementia in older Latinos; 3) conduct developmental research to
determine degree of knowledge and attitudes towards AD, brain health, and participation in all aspects of AD
research in older Latinos; and 4) serve as a conduit between the activities of the ADRC and a large-scale
epidemiology project on cognitive changes in older Latinos known as the Study of Latinos-Investigation of
Neurocognitive Aging (SOL-INCA) and other new national and state-wide Latino research initiatives. This will
allow participants identified with possible Mild Cognitive Impairment or ADRD to receive more extensive clinical
and neuropsychological characterization and to participate in AD-related research projects, including clinical
trials. Thus, the Latino Core will ensure that the ADRC is well positioned to...

## Key facts

- **NIH application ID:** 10407985
- **Project number:** 5P30AG062429-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Tamar Gollan
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $226,035
- **Award type:** 5
- **Project period:** 2019-05-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10407985

## Citation

> US National Institutes of Health, RePORTER application 10407985, Latino (5P30AG062429-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10407985. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*