ABSTRACT. This program will enhance the genomics capability at Morehouse School of Medicine, enabling a more comprehensive genomics initiative to be established focused on increasing the genomics workforce through providing student training opportunities in genomics, retraining of faculty, and translational research investigating the multiomics of cardiovascular disease. We propose this program in collaboration with our partners at Emory University, Georgia Institute of Technology, Children’s Health Care of Atlanta, and the Oak Ridge National Laboratories. The program will spur the development of education and training opportunities for students within the Atlanta University Center and therefore enhance the training and retraining of genomic researchers from these institutions. To organize the efficient performance of the program, we will establish a research management structure to enable continuous assessment. Our approach to enhance capacity at MSM center around the following activities. Genomics research. We propose a project that will generate datasets, provide education and training opportunities, and establish MSM as a center for comprehensive genomics research. The project will investigate whether blood epigenomic and transcriptomic profiles that predict patient outcomes or disease trajectory (prognosis) are associated with, independent of, or modified by exposomic factors. We propose to utilize blood samples and clinical data from an established research program at MSM to harness AI modeling to enhance prediction accuracy. Post-doc to faculty training. We will recruit two post-doctoral fellows who will undergo genomics research and professional development training over a three-year period for an eventual junior faculty position. The fellows will be aligned to research projects at MSM (either R series funded projects or the above project) and receive additional training in genomics analysis and AI/ ML training from our partner institutions. This approach will provide a pipeline for genomics capable faculty at MSM. Faculty retraining. To translate this research into enhanced education opportunities and retraining, we propose an education core that will focus on adapting an established Masters of Clinical Research course and developing new training modules for students and staff in computational skills and bioinformatics. Additional training opportunities will be created through our partnership with the established master’s program in clinical research to include genomics education modules with a focus on clinical applications. These modules will be utilized by trainees and established faculty wishing to re-train in genomics approaches for their research. Pilot projects. We propose to create a small grant program to enhance investigator development. A pilot genomics research program will be offered to MSM faculty. Funded projects will provide additional opportunities for trainees at our institution to gain access to and be involved with sh...