# Enhancing patient and organizational readiness for cardiovascular risk reduction among ethnic minority patients living with HIV

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $486,721

## Abstract

Project Summary
During this unprecedented time of social distancing, investigators and health systems must understand the
challenges faced by vulnerable patients and research participants and develop new strategies, including
telehealth, to provide continuity of research engagement and care delivery that reduce risks for
immunocompromised individuals, including people living with HIV (PLWH). The “Enhancing patient and
organizational readiness for cardiovascular risk reduction among ethnic minority patients living with HIV” parent
grant provides the Healing our Hearts, Minds, and Bodies (HHMB) intervention to Black and Latinx PLWH who
have both trauma histories and cardiovascular risks. The goal of the trial is to increase patient and
organizational readiness to address trauma and CVD risk among 260 Black and Latinx PLWH recruited from
two HIV clinics in Southern California. For these vulnerable patients, it is incumbent upon our team to continue
delivering the intervention while generating new knowledge in the context of the coronavirus (COVID-19)
pandemic. The unpredictable onset and course of COVID-19, and the health and environmental eﬀects that it
presents for our vulnerable participants, have uncovered many important challenges in conducting health
behavior research in high-risk, hard-to-reach populations. Current HHMB participants and those recruited for
future HHMB groups now face additional environmental exposure risks that can interact with their HIV status
and CVD risks, increasing negative health consequences, with severe ramiﬁcations that include death.
Therefore, it is critical to provide culturally relevant programming that will encourage sustained engagement
and maximize retention in research designed to reduce health risks as well as facilitate care. Retention efforts
are likely to prevent and control chronic disease, and reduce morbidity and premature mortality, leading to
improved overall health and wellness. In an eﬀort to follow current safer-at-home mandates, mitigate
environmental exposures, and provide continued health promotion, social support, and interaction during these
uncertain times, we propose to convert our intervention to a virtual platform. This conversion will enable
participants to receive services that are timely during COVID-19 and promote health on factors specific to the
parent grant (i.e., cardiovascular health, HIV, and trauma). We propose two supplemental aims that will be
achieved in an integrated mixed methods design: (1) to evaluate the impact of virtual delivery of the HHMB
intervention on clinical outcomes (e.g., Life’s Simple 7, depression, anxiety, post-traumatic stress); and (2) to
evaluate the evolving impact of COVID-19 on HHMB participants’: a) physical, mental, and emotional well-
being and self-care for HIV, CVD risk factors, and other chronic conditions; b) daily lives, including their access
to health care, needed social services, and other community resources; and c) engagement in and sat...

## Key facts

- **NIH application ID:** 10408469
- **Project number:** 3U01HL142109-04S2
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** ARLEEN F. BROWN
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $486,721
- **Award type:** 3
- **Project period:** 2018-08-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10408469

## Citation

> US National Institutes of Health, RePORTER application 10408469, Enhancing patient and organizational readiness for cardiovascular risk reduction among ethnic minority patients living with HIV (3U01HL142109-04S2). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10408469. Licensed CC0.

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