# Mouse Diabetes Clinic at Vanderbilt

> **NIH NIH P30** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2022 · $396,250

## Abstract

Metabolic Diabetes Clinic at Vanderbilt: Project Summary
Vanderbilt Diabetes Research Center (VDRC) investigators have been on the forefront of development,
standardization, implentation and dissemination of new concepts and technqiues to study mouse models of
metabolic diseases. The expertise of the VDRC has been available to the national research community for the
last 20 years through the NIDDK Mouse Metabolic Phenotyping Centers (MMPC) Program, with the Vanderbilt
MMPC playing a critical role. As the VDRC was engaged in strategic planning for this competitive renewal,
NIDDK made the decision to sunset the national MMPC program. Investigators outside Vanderbilt who had
used the VMMPC contacted us to express concern about how current and future scientific projects could be
conducted without the mouse services of the VMMPC. In response this input and a survey of more than 40
outside users, the VDRC proposes to create a national resource, the Mouse Diabetes Clinic at Vanderbilt
(MDC), to provide investigators nationwide with unique and sophisticated tools to study the mouse. The MDC,
led by experienced VDRC faculty and a highly skilled staff adept at complex procedures to study metabolism in
healthy, unstressed mice, will provide investigators outside Vanderbilt critically needed mouse-related services.
Skilled mouse surgeons will perform difficult catheter, cannula and probe implantations and provide surgery-
based mouse models to study diabetes and metabolism. Stable and radioactive isotopes will be used as
needed to delineate control of metabolic flux rates in mouse models of metabolic disease. Experience over the
past 5 in the VMMPC (> 13,000 services to 98 outside investigators from 66 institutions leading to 74 papers)
predicts a robust
MDC usage
. The MDC will also continue to provide important educational programs for the
diabetes community, including a weeklong course that has been given 20 times over 15 years focused on
mouse metabolic techniques. In summary, the MDC will facilitate diabetes research by providing novel services
that are feasible at few other institutions to a large number of diabetes investigators outside Vanderbilt.

## Key facts

- **NIH application ID:** 10408484
- **Project number:** 2P30DK020593-45
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** DAVID H WASSERMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $396,250
- **Award type:** 2
- **Project period:** 1996-12-01 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10408484

## Citation

> US National Institutes of Health, RePORTER application 10408484, Mouse Diabetes Clinic at Vanderbilt (2P30DK020593-45). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10408484. Licensed CC0.

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