# Generation of robust resident memory T cells in barrier tissues through skin vaccination

> **NIH NIH R01** · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $443,750

## Abstract

SUMMARY
COVID 19, the lower respiratory disease caused by the 2019 nCov virus, is the latest betacoronavirus to cause
epidemic disease in humans. Previously, SARS and MERS, both cause by related viruses, emerged and fell
dormant as epidemics. Betacoronaviruses use homologous “Spike” proteins to bind mammalian cells for entry
and infection, and most vaccines are being built to generate neutralizing antibodies to the unique 2019 nCov
Spike protein. In contrast, we are trying to create a “universal” betacoronavirus vaccine base on T cell
immunity, using proteins conserved between all known coronaviruses as immunogens. These proteins,
expressed by MVA vectors and delivered by epidermal disruption, should provide broad and durable
pulmonary immunity to past, present, and future betacoronavirus threats.

## Key facts

- **NIH application ID:** 10408492
- **Project number:** 3R01AI127654-05S1
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Rachael Ann Clark
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $443,750
- **Award type:** 3
- **Project period:** 2021-06-07 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10408492

## Citation

> US National Institutes of Health, RePORTER application 10408492, Generation of robust resident memory T cells in barrier tissues through skin vaccination (3R01AI127654-05S1). Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/grant/nih/10408492. Licensed CC0.

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