# Genetic Predictors of Prostate Cancer Survival

> **NIH NIH R01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $149,999

## Abstract

Abstract
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as
NOT-CA-21-049. Even though most men diagnosed with prostate cancer will not die of the disease,
prostate cancer is still the second leading cause of cancer death among men in the United States. While
screening for prostate cancer reduces death from disease, this comes at the price of both unnecessary
biopsies that reveal no evidence of cancer and treatment of otherwise indolent cancer resulting in
unnecessary adverse events. Therefore, there is an unmet need for improved screening tools for prostate
cancer. This need is especially important in the African-American population, as African-American men are
both more likely to be diagnosed with prostate cancer and to die from the disease if diagnosed. However,
to date, most genetic studies on prostate cancer have been conducted in individuals of European ancestry.
To address this need, we are conducting an NCI-funded study, “Genetic Predictors of Prostate Cancer
Survival”, whose goal is to identify genetic variants associated with survival time in men with prostate
cancer. This will be achieved both by testing both imputed gene expression levels, derived from common
variants, and pathogenic changes in coding genes, derived from rare coding variants, with survival. In the
initial grant, we proposed to validate our findings using several cohorts, including a series of 300 radical
prostatectomy patients from African-American patients from the Durham VA hospital we have collected.
Here, we are proposing to double the sample size by retrieving samples and extracting clinical annotation
for an additional 300 African-American men from this cohort. These samples will then be genotyped using
the resources of CIDR. With their deposition in dbGaP, this genetic data will both increase the power and
diversity of our studies of the genetics of prostate cancer survival and be of use to others studying genomic
influences on disease in African-Americans, both for their data on prostate cancer and as a reference panel
for other studies.

## Key facts

- **NIH application ID:** 10408510
- **Project number:** 3R01CA244948-01A1S1
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** ROBERT J. KLEIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $149,999
- **Award type:** 3
- **Project period:** 2021-01-15 → 2025-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10408510

## Citation

> US National Institutes of Health, RePORTER application 10408510, Genetic Predictors of Prostate Cancer Survival (3R01CA244948-01A1S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10408510. Licensed CC0.

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