# Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease

> **NIH NIH R44** · NEUROBEHAVIORAL SYSTEMS, INC. · 2022 · $250,000

## Abstract

Abstract. Hispanic Americans are the largest and fastest growing US minority and, over coming
decades, will show the largest relative increase in Alzheimer’s disease (AD) incidence of any
ethnic group. However, Spanish-speaking Hispanics have been largely excluded from clinical
trials and research studies for several reasons: (1) Only 5.5% of US neuropsychologists have
sufficient fluency to administer cognitive tests in Spanish; (2) Existing Spanish-language
cognitive tests lack adequate norms for older Hispanic Americans, and (3) many Hispanics live
in rural or hard-to-reach locations that make test administration challenging. Here, we propose
to create a Spanish version of the California Cognitive Assessment Battery (CCAB) and gather
normative data from 256 older Spanish-speaking Hispanics, telemedically tested in their homes.
CCAB-Spanish will significantly enhance access to cognitive testing for US Hispanics for
several reasons: (1) Automated and computerized test delivery and scoring means examiners
with limited Spanish fluency can administer CCAB-Spanish tests, with on-call interpreters as
needed; (2) Nationwide telemedical administration reaches populations underserved by manual
testing; and (3) A single examiner can remotely test multiple subjects concurrently making
clinical assessments of cognition economically feasible in economically disadvantaged
populations. The supplement will further enhance the long-term scientific and commercial
impact of the CCAB, and provide older Spanish-speaking US residents with improved access to
cognitive testing.

## Key facts

- **NIH application ID:** 10408563
- **Project number:** 3R44AG062076-04S1
- **Recipient organization:** NEUROBEHAVIORAL SYSTEMS, INC.
- **Principal Investigator:** Peter Pebler
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $250,000
- **Award type:** 3
- **Project period:** 2018-09-30 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10408563

## Citation

> US National Institutes of Health, RePORTER application 10408563, Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease (3R44AG062076-04S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10408563. Licensed CC0.

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