# Inhibition of an Apical cAMP/cGMP Transporter(MRP4)in the Gut InducesDiarrhea

> **NIH NIH R01** · CEDARS-SINAI MEDICAL CENTER · 2022 · $375,451

## Abstract

PROJECT SUMMARY
The unifying hypothesis to be tested in this proposal is that the compartmentalized regulation mediated by
Guanylate Cyclase-C (GC-C), Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Multiple
Drug-associated Protein-4 (MRP4) macromolecular complexes at or near the plasma membrane of gut
epithelial cells regulates cGMP mediated secretory diarrhea. We will test this hypothesis using transgenic
mice model (in vivo studies) and patient derived intestinal stem cells derived from crypts (enteroids) to study
fluid secretion in vitro. The proposed studies are highly significant because (i) it addresses the pathologies of
several deadly human diseases by utilizing models from humans and mice; (ii) it has clinical relevance and
implications; (iii) it is a multidisciplinary project covers basic biomedical studies, assay developments, and uses
personalized human stem cell cultures.

## Key facts

- **NIH application ID:** 10408698
- **Project number:** 5R01DK080834-16
- **Recipient organization:** CEDARS-SINAI MEDICAL CENTER
- **Principal Investigator:** Anjaparavanda P Naren
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $375,451
- **Award type:** 5
- **Project period:** 2009-08-20 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10408698

## Citation

> US National Institutes of Health, RePORTER application 10408698, Inhibition of an Apical cAMP/cGMP Transporter(MRP4)in the Gut InducesDiarrhea (5R01DK080834-16). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10408698. Licensed CC0.

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