# Oncology Tissue and Imaging Services

> **NIH NIH P30** · JOHNS HOPKINS UNIVERSITY · 2022 · $359,913

## Abstract

PROJECT SUMMARY/ABSTRACT
 The Oncology Tissue and Imaging Services (OTIS) Shared Resource (SR) provides a number of
technologies, services and scientific consultations to support the research of Sidney Kimmel Comprehensive
Cancer Center (SKCCC) Members and other Johns Hopkins University (JHU) investigators. The now
combined SR is comprised of the former Oncology Tissues Service (OTS) and Cell Imaging SRs. The OTIS
SR provides traditional G-band metaphase analysis and fluorescent in situ hybridization technologies, as well
as, light and fluorescence microscopy, stereo and confocal microscopy, infrared imaging, multiwell live-cell
time-lapse imaging and laser capture microdissection. In recent years, there has been tremendous growth in
the service of providing tissue cores from formalin-fixed paraffin-embedded tissue blocks for RNA and DNA
molecular analyses. Instrumentation and expertise are available to automatically capture high-resolution digital
images of both standard histology/IHC-based slides and TMA slides. The OTIS SR obtained an automated
slide stainer to convert laboratory discoveries of novel protein staining into clinical biomarkers. The SR also
provides web-based software tools and two back-end databases (TMAJ/Spectrum) to facilitate all facets of
research involving TMAs, routine slides and quantitative image analysis. Images can be acquired using a
variety of video and charge-coupled device cameras and then analyzed and manipulated with cutting-edge
image analysis software programs. The SR Manager is available for consultation before and during scheduled
imaging sessions. Users receive technical support and detailed instruction in the use of all SR equipment. The
SR Manager routinely monitors the performance of the SR's equipment and regularly receives updated
technical training from manufacturers to meet the constantly evolving needs of the SKCCC membership. A
Core Advisory Committee, composed of three senior SKCCC investigators, provides an additional level of
oversight of SR operations and provides guidance for the acquisition of new technologies and capabilities.
SKCCC Managed Shared Resource
Reporting Period: January 1, 2020 to December 31, 2020

## Key facts

- **NIH application ID:** 10409363
- **Project number:** 2P30CA006973-59
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** ALAN KEITH MEEKER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $359,913
- **Award type:** 2
- **Project period:** 1997-05-07 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10409363

## Citation

> US National Institutes of Health, RePORTER application 10409363, Oncology Tissue and Imaging Services (2P30CA006973-59). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10409363. Licensed CC0.

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