PROJECT SUMMARY/ABSTRACT Postmortem examinations of patients, where the procedure commences shortly after death (rapid autopsies), are becoming an important scientific engine for understanding mechanisms of disease progression and drug resistance, especially in this era of personalized medicine and immunotherapy. The Johns Hopkins Legacy Gift Rapid Autopsy Program is a Sidney Kimmel Comprehensive Cancer Center (SKCCC) Rapid Autopsy Program (RAP) Shared Resource (SR). It has been highly successful and was growing steadily prior to the onset of the SARS-CoV-2/COVID-19 pandemic. Services provided by the RAP SR include: 1) performing rapid research autopsies on patients who die of cancer to improve our understanding of tumor cell- intrinsic and tumor microenvironmental molecular alterations associated with disease progression, heterogeneity and drug resistance, including resistance to biological agents and immunotherapeutics; 2) providing histopathological expertise for diagnostic and quality control/assurance in interpretation of autopsy samples, including fresh frozen tissues and formalin-fixed paraffin-embedded (FFPE) tissues; 3) conducting biospecimen science studies to aid in the development and extension of best practices for consenting, tissue procurement, derivative specimen handling and sample storage; 4) expanding and maintaining a biorepository of fresh frozen and FFPE tissues, multitumor tissue microarrays, and fluid specimens from rapid autopsy cases, with full pathology and clinical annotations that can be accessed by qualified SKCCC and other investigators; and 5) developing and maintaining a web-based, secure and sharable whole-slide imaging archive of rapid autopsy histopathology and molecular pathology specimens. SKCCC Managed Shared Resource Reporting Period: January 1, 2020 to December 31, 2020