# Neuropathology Core

> **NIH NIH P30** · STANFORD UNIVERSITY · 2022 · $365,632

## Abstract

1. SUMMARY (Neuropathology Core)
The Neuropathology Core supports the vision of the Stanford Alzheimer’s Disease Center (ADRC) to serve as
a shared resource to facilitate and enhance multidisciplinary and interdisciplinary research in Alzheimer’s
disease (AD) and related disorders. The Core is structured to continue its track record of enabling and applying
innovative cutting-edge technologies with emphasis on brain aging and the diversity of pathologic processes
that underlie cognitive impairment and dementia caused by AD and related diseases. The critical functions of
the Neuropathology Core include diagnostic expertise, serving as a biorepository, facilitating innovation, and
training. Over the past five years, the Neuropathology Core has completed over 50 research brain autopsies
and held a leadership position in setting and evaluating national research guidelines for neuropathologic
evaluation of AD. We have banked over 800 tissue specimens, contributed data and biospecimens to local,
regional, national, and international research studies and consortia, and fostered development and
implementation of innovative technologies in translational research. Through the Core, we trained clinicians
and scientists from different disciplines in neuropathology and the molecular pathology of dementia-related
neurodegenerative diseases. The Neuropathology Core will pursue its mission through four Specific Aims. The
Core will provide comprehensive neuropathologic evaluations for physicians and researchers with timely and
comprehensive autopsy reports that describe the neuropathologic features of AD and related diseases
according to the most current guidelines and consensus diagnostic criteria. It will maintain and continue to
grow its highly accessible, but appropriately safeguarded, repository of brain tissue and biospecimens from
carefully and longitudinally characterized patients with cognitive impairment or dementia, as well as cognitively
normal individuals, using methods that increase and maximize tissue and data quality. In doing so, the Core
will empower innovative high-content imaging approaches for both formalin-fixed, paraffin-embedded tissue
and for frozen brain regions to maximize the research value of the Stanford ADRC repository and other brain
banks around the country. Finally, we will maintain a rich training environment for medical and graduate
students, residents, fellows, and junior faculty across departments to teach concepts and state-of-the-art
techniques that advance current interdisciplinary research and foster future advances and insights in brain
aging and neurodegeneration. The Core is organized to maximize integration with all other Cores in the
Stanford ADRC. It also will continue to serve as a hub of support for affiliated ADRCs and independent
research awards through diagnostic practices, molecular assays, and tissue sharing. In doing so, the Core and
Center will continue to contribute nationally to advance our understanding ...

## Key facts

- **NIH application ID:** 10409745
- **Project number:** 5P30AG066515-03
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Thomas J Montine
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $365,632
- **Award type:** 5
- **Project period:** 2020-06-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10409745

## Citation

> US National Institutes of Health, RePORTER application 10409745, Neuropathology Core (5P30AG066515-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10409745. Licensed CC0.

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