# Role of cleaved H3 as a key epigenetic regulator of macrophages in idiopathic pulmonary fibrosis

> **NIH NIH F30** · STANFORD UNIVERSITY · 2021 · $38,366

## Abstract

Project Summary
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with a median survival of 2-5 years.
The incidence of IPF increases with age, thus IPF will affect more individuals as the population continues to grow
older. There is no effective treatment for IPF except lung transplantation. Our current understanding of IPF
suggests that pathogenesis begins when environmental factors alter normal lung homeostasis in a genetically
or epigenetically susceptible individual. This altered state disrupts normal cell communication and induces a
wound healing response, ultimately leading to irreversible fibrosis of the lung parenchyma. Although the exact
etiology of IPF is unknown, pro-fibrotic macrophages have been implicated in disease pathogenesis. Preliminary
data suggests that patients with IPF have a population of disease-specific macrophages. This proposal aims to
elucidate the role of specific histone modifications on disease-specific macrophage transcriptome in IPF. Aim 1
combines biochemical and genetic tools to identify the targets and regulators of histone modifications in IPF-
specific macrophages. Aim 2 will evaluate the transcriptional changes directly caused by presence or absence
of a histone modification in macrophages. These experiments will elucidate a mechanism of macrophage
dysfunction with direct translational implications for patients with IPF.

## Key facts

- **NIH application ID:** 10410347
- **Project number:** 5F30HL149252-02
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Madeleine Scott
- **Activity code:** F30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $38,366
- **Award type:** 5
- **Project period:** 2020-06-14 → 2022-06-13

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10410347

## Citation

> US National Institutes of Health, RePORTER application 10410347, Role of cleaved H3 as a key epigenetic regulator of macrophages in idiopathic pulmonary fibrosis (5F30HL149252-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10410347. Licensed CC0.

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