# Biomarker and Neurogenetics Core

> **NIH NIH P30** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $264,438

## Abstract

Core G: Biomarker and Neurogenetics Core (BNGC): Summary/Abstract:
The Biomarker and Neurogenetics
(BNG) Core builds on the existing strengths of genetics of dementia and Alzheimer’s disease (AD) biomarkers
at the University of Pittsburgh. Over nearly 25 years, we have amassed DNA and plasma samples along with
endophenotype data from approximately 12,000 University of Pittsburgh ADRC (PITT-ADRC) and non-ADRC
participants. This rich resource has enabled our research team to play a significant role in understanding the
complex genetic architecture of late-onset AD and AD-related endophenotypes. The goal of the BNG Core is to
continue collecting and archiving DNA and blood samples from new and existing AD patients and controls in
order to enlarge case-control and endophenotype samples and to augment the amount of existing DNA and
plasma that would be critical to current and future efforts in identifying new genetic markers and plasma
biomarkers for AD in Pittsburgh and at external sites. Specifically, we will collect and bank DNA and plasma
from blood samples and obtain endophenotype data from ADRC and non-ADRC ancillary studies (aim1);
generate APOE and other new genetic risk markers associated with AD and provide the genetic data to
qualified investigators (aim 2); and generate plasma Aβ and neurofilament light (NFL) biomarkers data and
provide this to studies assessing the utility of blood-based biomarkers to predict individual Aβ and tau
deposition, as well as neurodegeneration, as determined by PET and MRI imaging.

## Key facts

- **NIH application ID:** 10410387
- **Project number:** 5P30AG066468-03
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** M. Ilyas Kamboh
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $264,438
- **Award type:** 5
- **Project period:** 2020-05-15 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10410387

## Citation

> US National Institutes of Health, RePORTER application 10410387, Biomarker and Neurogenetics Core (5P30AG066468-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10410387. Licensed CC0.

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