Project Summary Training in the application of chemical principles is essential for modern research across a number of disciplines ranging from Chemistry and Biochemistry to Biology, Engineering and Medicine. Acknowledging this need, NC State University has launched a new research and training program called the Chemistry of Life Program (CLP) and initiated an innovative graduate training program, the Chemistry of Life Training Program (CLTP), as a core element. A key aspect of this program is core training, both lecture and experimental, in core chemical biology principles and techniques. This not only facilitates completion of the students’ dissertation research, but also lays the basis for career opportunities in academic, government, and industrial research settings. To achieve this, the CLTP has partnered with the Comparative Medicine Institute and Biotechnology Training Program to synergize this program across our campus though at least 4 Colleges and 7 Departments. A trans-departmental Executive Committee will lead the operation of the CLTP and oversee sub-committees focusing on program elements. The specific objectives of the training program are: 1) Ensure technical proficiency and training in responsible and rigorous science; 2) Provide an educational and training experience that is in line with graduate students’ expectations for an interdisciplinary future; and, 3) Nurture robust PhD graduation outcomes. Six slots (three in year 1) are requested that will be augmented by four slots (two in year 1) from University resources. The program requirements include a minor in the Chemistry of Life; a course in professional development/ scientific rigor and reproducibility; courses in research ethics; and an annual research symposium/retreat. These requirements are in addition to those associated with the student’s particular Department or Program for the doctoral degree. During their two-year appointment to the training grant, trainees will also benefit from an exploratory laboratory rotation program, co-mentorship across disciplines, access to development workshops on topics like research commercialization, and the opportunity to be guided through mentorship of undergraduate researchers on a team science project. This program will also provide a central focus for faculty of the various disciplines involved in this training effort to seek out new opportunities for formal and informal research collaboration as part of the broader CLP program.