Project Summary CREATE’s newly structured Data and Technical Development Core (DTDC), formerly Data Core, includes bio- statistical, data management, programming, and software development (including expertise in artificial intelligence, machine learning, & Virtual Reality), and cybersecurity expertise. The DTDC will have access to the resources at the Cornell Tech Campus and the Design & Environmental Analysis Center at Cornell Ithaca and will also be supported by technical resources at Florida State University (FSU) and the University of Illinois at Urbana-Champaign (UIUC). The DTDC will continue to provide an infrastructure for the coordination, collection, management, and sharing of data; and provide critical statistical support including assistance with sampling, analysis, and design and recruitment strategies for all research projects (including the Pilot Research projects). The Core has detailed cybersecurity protection protocols that involve hardware, software, and participant training solutions. Cybersecurity protection protocols will be applied to all data, projects, and study participants and users will be queried about annoyance. The DTDC will also ensure that research activities are conducted in compliance with regulatory agencies with regard to privacy and confidentiality. The DTDC will collaborate with the Administrative Core (AC) in the development of data collection, entry, and training protocols for all research personnel. The Core will also be responsible for providing the investigators with technology support for the research projects. This will include the development of technology interfaces (e.g., VR), the development of novel intelligent adaptive systems using machine learning, digital assistants, and other types of technology tools. The Core will continue to use a variety of methods for data collection, including computer- assisted instruments and computer-aided telephone interviewing software (CATI). During CREATE V, these protocols will be expanded and adaptive data collection tools on mobile devices for study participants will be included. Server-side applications for data collection (e.g., REDCap) will be implemented for survey data collection. The DTDC will also develop data documentation manuals and data libraries for the projects and assume responsibility for data scoring and integration. The Core will be responsible for: processing all data to ensure its accuracy, consistency, and integrity; continuing to serve as a central repository for all Center related data and documents; providing a framework to facilitate collaboration between Center personnel; and implementing our detailed resource sharing plan (see Resource Sharing Plan). It will also continue to maintain the SharePoint Server for the Center to share libraries of data, documents, presentations, etc. The DTDC will continue to work with the AC in the preparation of project reports such as the progress reports for the NIH and the External Scientific Board and...