Project Summary/Abstract The Postdoctoral Training Program in Hepatology is an integral part of the comprehensive hepatology research program at UCSF. The purpose of the program is to provide trainees a solid background in liver biology and disease and the investigational skills to address new questions and contribute to new knowledge in hepatology. The program is staffed by 16 faculty based within the Departments of Medicine, Surgery, Pediatrics and Bioengineering & Therapeutic Sciences; collectively these individuals offer balanced expertise in basic and clinical hepatology and have a strong track record of working collaboratively with each other. A subgroup of six program faculty comprise a Steering Committee charged with screening and selecting applicants, reviewing the training curriculum and monitoring the progress of active trainees. An External Advisory Board provides independent counsel. At the recruitment stage, faculty preceptors are trained to use holistic methods to screen and select applicants in an equitable fashion. Faculty in charge of admitted trainees are educated in mentoring best practices, including mentoring across differences. For the trainees themselves, the program prioritizes structured individual development plans and encourages the use of mentoring teams that include career and content mentors. The postdoctoral training plan begins with a foundational core curriculum covering liver biology, liver-related research methods and general academic skills. Formal instruction in rigor, reproducibility and responsible conduct of research is required. Along with this, trainees pursue specialized research instruction in a selected topic area ranging from clinical epidemiology and health outcomes cell biology, immunology, metabolism and fibrosis/carcinogenesis. Focused scientific coursework is available to all trainees if desired; for those pursuing clinical investigation who do not have an advanced degree, enrollment in a Master’s Degree program is mandatory. Commensurate with scientific training, postdocs receive support for career development to facilitate their transition to independence. Importantly, the T32 program benefits from the rich research and training infrastructure at UCSF that encompasses an array of core facilities as well as a wealth of resources for trainee wellness and personal/professional support. Key among these are the UCSF Liver Center, the Clinical and Translational Science Institute, the Office of Diversity and Outreach and the Office of Career and Professional Development. Our program faculty are strong figures in several of these units, and accordingly they can guide trainees to utilize the resources to maximize the value of their postdoctoral experience. The ultimate goal of the training program is to provide sufficient group and individual mentorship to enable graduates to assume a faculty-level position and compete successfully for independent research funding in hepatology.