PROJECT SUMMARY Shared Resources are organized and maintained to meet the scientific needs of members of the Stanford Cancer Institute (SCI). Through SCI-supported Shared Resources, SCI members have access to state-of-the-art equipment, instrumentation, technical expertise, training, and education—all designed to support highly innovative cancer research. As a matrix Cancer Center, the SCI is solely responsible for the management of two Shared Resources and supports nine others that are jointly managed with the School of Medicine (SOM) and University. CCSG funds are being requested for the support of the following eleven shared resources: Animal Tumor Models, Biomedical Informatics, Bioscience Screening, Biostatistics, Cancer Imaging, Cell Sciences Imaging, Flow Cytometry, Genomics, Human Immune Monitoring, Proteomics, and Tissue Procurement. In 2020, Dr. Artandi appointed Holden Maecker, PhD, Professor of Microbiology and Immunology, as the Associate Director for Shared Resources. Maecker is also the Director of the Service Centers and Enabling Technologies for the SOM, providing integration of SCI member needs into the overall shared resource planning and evaluation process. SCI administration oversees the management and reporting of the Shared Resources and receives feedback through annual surveys of users and from the Shared Resources internal advisory boards. The Senior Leadership Cabinet provides oversight for the overall scientific and strategic development of Shared Resources. Over the current funding period, the $6M amount of funding for the Shared Resources from the CCSG was augmented by $2.1M annually in SCI institutional support with a strong return on investment as documented by usage metrics and publications. The CCSG budget contribution to SCI Shared Resources is only $1.1M (8%) of the total operational budget ($14.4M, including CCSG and SCI funds) for all Shared Resources in CY20, with the remainder supported by institutional funds and chargebacks or grant support. The SCI requests $1.5M in annual support for eleven Shared Resources and two developing Shared Resource in the next funding period, which will be leveraged by additional $2M in SCI funds.