# Hybrid Rat Diversity Program

> **NIH NIH R24** · MEDICAL COLLEGE OF WISCONSIN · 2022 · $779,449

## Abstract

Project Summary
The ongoing goal of this program is to extend the use of rat models for clinical translation
through establishing an animal resource and genomic dataset to facilitate the translation of
laboratory research to clinical relevance. Specifically, the Hybrid Rat Diversity Panel (HRDP)
resource provides the research community with a foundation for systems genetics and a tool for
forward genetics. To achieve this goal, we propose the following four specific aims: 1) to
continue to establish the 96 strain Hybrid Rat Diversity Panel comprised of 33 classic inbred
strains, 30 HXB/BXH recombinant inbred strains and 33 FXLE/LEXF recombinant inbred strains
through embryo rederivation and importation, 2) to characterize, maintain and distribute the
HRDP, 3) to provide genomic and transcriptomic sequencing of the HRDP and 4) and provide
data analysis, integration and dissemination primarily through the Rat Genome Database
(RGD). This resource will be used to study mechanisms of complex disease traits through
systems genetics by providing investigators with access to a renewable panel of inbred rat
strains and biobanked tissues, reusable phenotypic data, reusable genomic and transcriptomic
data, and the infrastructure to explore, analyze and visualize these resources through the HRDP
Portal at RGD. Experimental rats and biobanked tissues from the entire HRDP panel can be
used for other omic studies, including the epigenome, proteome, and metabolome. The Rat
Resource & Research Center (RRRC) is partnering with the HRDP to provide the rat models to
the research community. The HRDP will have broad utility to the scientific community through
the genetic and phenotypic diversity represented in the 96 strain panel used to study
hypertension, stroke, diabetes, cancer, arthritis, reproductive disorders, asthma, aging, alcohol
preference, anxiety, exercise and addiction.

## Key facts

- **NIH application ID:** 10411190
- **Project number:** 2R24OD024617-05
- **Recipient organization:** MEDICAL COLLEGE OF WISCONSIN
- **Principal Investigator:** MELINDA R DWINELL
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $779,449
- **Award type:** 2
- **Project period:** 2018-08-01 → 2026-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10411190

## Citation

> US National Institutes of Health, RePORTER application 10411190, Hybrid Rat Diversity Program (2R24OD024617-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10411190. Licensed CC0.

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