# Animal

> **NIH NIH P01** · UNIVERSITY OF ARIZONA · 2022 · $310,623

## Abstract

PROJECT SUMMARY – ANIMAL CORE
Each year ~1.5 million American women enter into the perimenopause, a neuroendocrine transition state unique
to the female. The mission of the Perimenopause in Brain Aging and Alzheimer’s disease (P3) is to discover
biological transformations in brain that occur during the perimenopausal transition that lead to endophenotypes
predictive of risk for Alzheimer’s disease (AD). Herein, we focus on the neuro-immune system as a key driver of
chronological and endocrinological aging that occurs in the midlife female brain. Our goals are to identify the
mechanisms by which these transformations occur and to translate these discoveries into strategies to prevent
conversion to an at-Alzheimer's-risk phenotype. Animal Core contributes to meeting P3 goals through provision
of veterinary service and support to Projects 1–3. To achieve its mission, Animal Core will maintain and track
animals using the Electronic Veterinary Management Platform, provide humanized APOE Perimenopause
Animal Model (PAM) model to projects, conduct physiological and behavioral assessment, perform intervention
regimen, and conduct tissue collection for analyses by Analytic Core and/or individual Projects across the entire
Perimenopause Program Project. During previous P3 periods, we developed a rodent model of human
perimenopause that recapitulates key features of human perimenopause. Using this model, our investigation
provided new mechanistic insights into the biological transformations in chronological and endocrinological aging
in female brains. Animal Core will continue to serve as an instrumental resource to achieve the Program Project’s
overall mission and aims by providing scientifically validated and translationally relevant animal models.
Outcomes of Animal Core support will enable achieving the Perimenopause in Brain Aging and Alzheimer’s
Disease Program Project mission and aims through the veterinary care and testing capabilities it has developed
Research proposed herein addresses strategic goals of the National Institutes on Aging’s 2016: Aging Well in
the 21st Century: Strategic Directions for Research on Aging, specifically Goals A1, 2, 3, 7, 8 & 11 and Goals
D1, 2, & 4.

## Key facts

- **NIH application ID:** 10412247
- **Project number:** 5P01AG026572-17
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Tian Wang
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $310,623
- **Award type:** 5
- **Project period:** 2006-08-15 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10412247

## Citation

> US National Institutes of Health, RePORTER application 10412247, Animal (5P01AG026572-17). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10412247. Licensed CC0.

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