# Associations among in utero exposure to metals/metal mixtures,stress/stress mixtures, and internalizing problems in early childhood

> **NIH NIH UH3** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $40,809

## Abstract

The overall goal of Brandon Goldson’s supplemental research is to leverage the parent project’s
exposure expertise and measures (metals, stress) to address a research gap by examining
associations between these exposures, starting prenatally, and early childhood antecedents of
mental health risk. The project will also leverage planned urinary metals assays for n~3,000
PRISM ECHO prenatal samples which can be pooled with this supplement through Big Win
analysis proposal HHEAR EC0376, and stress measures and the Child Behavior Checklist
(CBCL) collected through the ECHO-wide cohort protocol with guidance on harmonization
across life stage by PRO Core investigators, to examine the influence of complex metal and/or
stress mixtures on transdiagnostic (TD) features linked to anxiety and depressive problems
assessed up to ages 3-6 years. The proposal includes collaborations with ECHO HHEAR and
PRO Core components. This supplement will support Brandon Goldson to work with the
PRISM/ECHO investigator team at the Icahn School of Medicine at Mount Sinai to
conduct and interpret analyses focused on both 6-mo and 3-yr outcome data and to gain
experience in manuscript preparation. This opportunity will expand his knowledge in the role
of metals in neurotoxicity, specifically their potential impact on early psychopathology which
remains largely unexplored. He will also gain a greater understanding of the importance of
interactions between chemicals and social stressors in relation to health disparities. The goal is
to have 2 first-authored manuscripts, with one submitted and published prior to his applications
to residency programs following the completion of medical school. This will strengthen his
planned applications for research residency programs to further his research training.

## Key facts

- **NIH application ID:** 10412666
- **Project number:** 3UH3OD023337-06S1
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Robert O Wright
- **Activity code:** UH3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $40,809
- **Award type:** 3
- **Project period:** 2016-09-21 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10412666

## Citation

> US National Institutes of Health, RePORTER application 10412666, Associations among in utero exposure to metals/metal mixtures,stress/stress mixtures, and internalizing problems in early childhood (3UH3OD023337-06S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10412666. Licensed CC0.

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