# Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children - Diversity Supplement

> **NIH NIH UH3** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $66,525

## Abstract

Abstract – Parent Grant
The proposed UC Davis ECHO ReCHARGE Study will follow a cohort of children last seen at ages 2-5 years
(`baseline') to determine environmental chemical and non-chemical stressors and resiliency factors that are
associated with neurodevelopmental outcomes at ages 8-12 years (pre-adolescent) and 15-19 years (mid- to
late adolescence). This project leverages the resources of the CHARGE (Childhood Autism Risks from Genes
and Environment) Study, which, since 2003, has been enrolling three groups aged 2-5 years: children with
autism spectrum disorder (ASD), children with other developmental delays (DD) and children from the general
population with typical development (TD). These three groups, the ReCHARGE cohort, will be examined for
the following outcomes of interest: attention deficit or hyperactivity symptoms; changes in cognitive or adaptive
function; changes in severity or diagnosis; and symptoms of anxiety or depression. Pilot testing will take place
in the UG3 phase, and in the UH3 phase, all will be examined either in pre-adolescence or mid- to late
adolescence. The primary exposures of interest are pesticides, metals, air pollution, phthalates, nutrients,
neighborhood characteristics, and family factors. Additionally, three mechanistic studies are proposed: an
investigation of intergenerational epigenetic profiles; method development for metals analysis in dried blood
spots; and sex specific associations of adrenal hormones with depressive symptoms. Approximately 1400
families are eligible for ReCHARGE, providing a robust sample for examination of main effects, interaction and
mediation analyses. As part of the ECHO consortium, the ReCHARGE team will participate in the synthetic
cohort combining children from multiple sites, and the cluster of studies focused on neurodevelopment in
harmonizing protocols for the prospective UH3 phase and in seeking to analyze retrospective samples and
data collaboratively, where feasible. During the UG3 phase, the ReCHARGE team will develop protocols, pilot
test methods for recontacting and recruiting, for epigenetics in saliva vs. blood, and for implementation of the
adrenal hormone study, including ways to increase compliance. Unique features of ReCHARGE include the
contribution to understanding life course development in children with two different types of disabilities, and a
novel model of adrenal hormone relationships with sex-specific affective disorders.

## Key facts

- **NIH application ID:** 10412853
- **Project number:** 3UH3OD023365-06S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Deborah Hall Bennett
- **Activity code:** UH3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $66,525
- **Award type:** 3
- **Project period:** 2016-09-21 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10412853

## Citation

> US National Institutes of Health, RePORTER application 10412853, Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children - Diversity Supplement (3UH3OD023365-06S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10412853. Licensed CC0.

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