# Neuronal Mechanisms of Good-Based Economic Decisions

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 2022 · $467,147

## Abstract

ABSTRACT
Economic choice behavior is specifically disrupted in mental disorders such as frontotemporal dementia, major
depression and drug addiction. To shed light on these diseases and to pave the way for treatments, it is critical
to understand the neural underpinnings of this behavior. In this respect, the past 15 years witnessed very
significant progress. Evidence from clinical data, lesion studies, functional imaging and neurophysiology links
economic choice to the orbitofrontal cortex (OFC). In particular, work in my lab examined the activity of OFC
neurons in monkeys choosing between different juices. We thus identified three populations of cells intimately
related to choices: offer value cells encoding individual offer values, chosen juice cells encoding the binary
choice outcome, and chosen value cells. In a recent breakthrough, we used electrical stimulation to show that
offer values encoded in OFC are causal to choices. Together with work from other labs, our results lay the
foundations for a satisfactory understanding of economic choices. However, at least three major questions
remain open. (1) It is unclear where in the brain and how value comparisons (i.e., decisions) take place. (2) It is
unclear where and how offer values are first computed (or “constructed”). (3) It is unclear whether offer values
represented in other brain regions – such as the amygdala – are also causal to choices. The overarching goal
of this proposal is to address these fundamental questions. All the experiments will be conducted in non-
human primates. Using a combination of behavioral manipulation, neuronal recordings, electrical stimulation
and computational techniques, we will pursue two Specific Aims.
Under Aim 1, two experiments will examine whether neurons in the OFC participate in value comparison. The
cell groups identified in this area represent both the input (offer value) and the output (chosen juice, chosen
value) of the decision process, suggesting that they constitute the building blocks of a decision circuit. Exp.1
will assess whether the three cell groups are stable across choice conditions. In parallel, Exp.2 will use
electrical stimulation to assess whether neuronal activity in OFC is necessary for value comparison. Under
Aim 2, we will examine whether and how three brain regions interconnected with OFC – gustatory cortex (GC),
inferotemporal cortex (IT) and basolateral amygdala (BLA) – are involved in the choice process. A working
hypothesis is that GC and/or IT might participate in the construction of offer values. Two experiments will test
this hypothesis by recording neuronal activity from these two areas. Work conducted in the previous cycle
found that neurons in BLA encode the same variables represented in OFC, with some differences. In the last
experiment, we will use electrical stimulation to assess (a) whether offer values encoded in BLA are causal to
choices and (b) whether BLA participates in the decision process. Fulfilling thes...

## Key facts

- **NIH application ID:** 10412898
- **Project number:** 5R01MH104494-07
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Camillo Padoa-Schioppa
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $467,147
- **Award type:** 5
- **Project period:** 2015-05-15 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10412898

## Citation

> US National Institutes of Health, RePORTER application 10412898, Neuronal Mechanisms of Good-Based Economic Decisions (5R01MH104494-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10412898. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*