# Core D: Long-term Follow-Up

> **NIH NIH P01** · FRED HUTCHINSON CANCER CENTER · 2022 · $417,866

## Abstract

PROJECT SUMMARY 
This core supports Projects 1 – 3 by collecting long-term follow-up data for patients who have had 
hematopoietic cell transplantation (HCT) or genetically modified T cell therapy at the Seattle Cancer Care 
Alliance (SCCA), University of Washington (UW) or Seattle Children's Hospital (SCH) under protocols 
developed at the Fred Hutchinson Cancer Research Center (FHCRC). The services of this core unit address 
several closely related areas: identification and management of late complications, data and research sample 
collection, database assembly and evaluation of the efficiency, accuracy, quality and utility of the data 
collection and the system in which the data are stored. We have developed several mechanisms to support 
this overall goal. 
 1. We will collect long-term data focused on survival, therapy-related complications, and health relevant to 
 the clinical research studies sponsored by this grant. This includes the prospective cohort of patients to 
 be enrolled in studies described in Projects 1 – 3 of this grant application, some of whom will be 
 receiving genetically modified cells and thus follow-up for at least 15 years after treatment is 
 recommended. For this purpose, a system has been established to track and maintain contact with 
 patients and referring physicians so that data can be collected at specified time points after treatment. 
 2. We will assist investigators in obtaining information and research biospecimens that are not routinely 
 collected but are needed for individual research projects. 
 3. We will continue to identify barriers that interfere with long-term follow-up of geographically dispersed 
 patients and develop methods to overcome these barriers. 
 4. We will continue to evaluate the research methods employed in data collection and database 
 management, including the efficiency, reliability, validity and utility of the instruments used for data 
collection. 
The data generated from this core unit will assist project leaders in understanding the long-term efficacy of 
experimental treatments and identifying late complications after cellular therapy with HCT or genetically 
modified T cells. Close coordination with the clinical Long-Term Follow-Up Program (LTFU) that provides 
telemedicine services ensures prompt notification of clinical events. Integrating long-term data collection 
efforts across the Projects through Core D provides efficient services to support this Research Program.

## Key facts

- **NIH application ID:** 10412946
- **Project number:** 5P01CA018029-47
- **Recipient organization:** FRED HUTCHINSON CANCER CENTER
- **Principal Investigator:** STEPHANIE J LEE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $417,866
- **Award type:** 5
- **Project period:** 1997-08-28 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10412946

## Citation

> US National Institutes of Health, RePORTER application 10412946, Core D: Long-term Follow-Up (5P01CA018029-47). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10412946. Licensed CC0.

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