# 1Florida Alzheimer's Disease Research Center Neuropathology Core

> **NIH NIH P30** · UNIVERSITY OF FLORIDA · 2022 · $226,982

## Abstract

In order to support the goals of the 1Florida Alzheimer’s Disease Research Center (1Florida ADRC) the 
Neuropathology Core will perform diagnostic evaluations and quantitative analyses of the brains collected from 
deceased individuals that participate in the clinical studies. A definite diagnosis of AD still requires a thorough 
post-mortem evaluation. We will coordinate storage of biospecimens including blood plasma, serum, DNA, and 
CSF and their distribution in response to request from qualified investigators inside and outside the 1Florida 
ADRC. The specific aims of the Neuropathology Core are: Aim 1 Conduct a thorough post-mortem CNS 
examination in accordance to National Institute on Aging-Alzheimer’s Association consensus guidelines of ~25 
ADRC subjects/year followed longitudinally in the Clinical Core with consent and establish a neuropathological 
diagnosis for each patient. Aim 2 Provide neuropathologic data to be included in the database using support 
from the Data Management and Statistical (DMS) Core and provide ADRC data in concert with the Clinical 
Core. Neuropathological data will be provided to the National Alzheimer Coordinating Center (NACC) through 
the Data Management and Statistical Core Aim 3 Collect and maintain a bank of archived unfixed frozen and 
fixed tissue, DNA, cerebrospinal fluid (CSF), serum and plasma from ADRC patients with AD, MCI, preMCI or 
other related neurodegenerative diseases, along with CN controls and distribute these samples to qualified 
investigators within the ADRC and external investigators upon request. Aim 4 Be responsive to changing needs 
in tissue acquisition and processing to support new scientific studies and provide consultation regrading 
appropriate experimental design for neuropathology studies in both human samples and mouse models of 
various inclusion pathologies relevant to neurodegenerative disorders. Aim 5 Execute clinical pathologic case 
conferences, brain cutting and other activities supporting research training activities and ensure integration with 
other Cores within the 1Florida ADRC. Final diagnoses will be achieved by clinical-pathological consensus 
conferences to be held quarterly with the Clinical Core, which will serve as an important educational component 
that will integrate with the Research Education Component. These activities of this Core are all critical functions 
of an ADRC.

## Key facts

- **NIH application ID:** 10413194
- **Project number:** 5P30AG066506-03
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Stefan Prokop
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $226,982
- **Award type:** 5
- **Project period:** 2020-06-15 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10413194

## Citation

> US National Institutes of Health, RePORTER application 10413194, 1Florida Alzheimer's Disease Research Center Neuropathology Core (5P30AG066506-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10413194. Licensed CC0.

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