# Functional consequences of stem and progenitor cell heterogeneity

> **NIH NIH P01** · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $50,400

## Abstract

OVERALL PROJECT SUMMARY
This program brings together five hematopoiesis investigators who have been working collaboratively to
address the fundamental question of how individual hematopoietic stem and progenitor cells (HSPC) are
regulated to contribute to the production of blood under homeostatic and stress conditions. It creates a
collective of complementary technologies developed in the investigator's laboratories to track individual clones
in vivo and thereby to model how distinct clonal behaviors contribute to hematopoietic output under varying
conditions. Furthermore, it employs innovative tools for manipulating specific molecular regulators of gene
expression to test which molecules drive specific HSPC behaviors. These are tested in the context of
inflammatory and genotoxic stress and are evaluated for their ability to alter the competitive relationship of
normal HSPC with clones bearing blood disease associated alleles known to accumulate in the aging human.
The cross comparison of models, species, time in development and molecular parameters (mRNA, meDNA,
ncRNA, chromatin state) shared through an established common database and analytic tools provide a
uniquely powerful means of defining with high resolution the process of hematopoiesis. By providing a
mechanism to sustain interaction, share data and techniques and create a forum for resolution of conflicting
data, this PO1 will facilitate the creation of a hematopoiesis `roadmap' whereby interventions at specific
molecular waypoints can modulate blood cell production to enhance hematopoietic regeneration and limit
aberrant clonal outgrowth in settings of disease.

## Key facts

- **NIH application ID:** 10413502
- **Project number:** 3P01HL131477-05S1
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** David T Scadden
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $50,400
- **Award type:** 3
- **Project period:** 2020-06-15 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10413502

## Citation

> US National Institutes of Health, RePORTER application 10413502, Functional consequences of stem and progenitor cell heterogeneity (3P01HL131477-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10413502. Licensed CC0.

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