# Fundamental mechanisms of paternal mitochondrial eliminationand radiation-induced bystander effects

> **NIH NIH R35** · UNIVERSITY OF COLORADO · 2022 · $615,244

## Abstract

Project summary
Paternal mitochondrial elimination and radiation-induced bystander effects are two vitally important, distinct,
and dynamic biological processes essential for animal development, stress response, and organismal fitness.
Defects in these two important processes can cause various pathological conditions and disease. In this
proposed work, we will carry out molecular genetic, reverse genetic, biochemical, cell biological and proteomic
analyses to decipher basic mechanisms that regulate paternal mitochondrial elimination and radiation-induced
bystander effects. For the study of paternal mitochondrial elimination, we hope to understand how paternal
mitochondria are selectively impaired, recognized and removed in fertilized eggs, what paternal and maternal
mechanisms are employed to specifically eliminate paternal mitochondria, and why paternal mitochondria need
to be removed to ensure animal development and cell and organismal fitness. For the study of radiation-
induced bystander effects, we plan to identify factors involved in triggering bystander effects in unexposed
cells, signal pathways that mediate different bystander responses, and the mechanistic basis of bystander
responses to other stresses. These studies should reveal novel mechanisms, pathways, and genes that control
these two fundamental biological processes, and ultimately, provide new targets, ideas, and strategies to
facilitate treatment of numerous human diseases caused by abnormalities in paternal mitochondrial elimination
and improve disease treatment by reducing side effects caused by radiotherapy and other therapeutic
treatments.

## Key facts

- **NIH application ID:** 10413845
- **Project number:** 5R35GM118188-07
- **Recipient organization:** UNIVERSITY OF COLORADO
- **Principal Investigator:** DING XUE
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $615,244
- **Award type:** 5
- **Project period:** 2016-06-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10413845

## Citation

> US National Institutes of Health, RePORTER application 10413845, Fundamental mechanisms of paternal mitochondrial eliminationand radiation-induced bystander effects (5R35GM118188-07). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10413845. Licensed CC0.

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