# The Development and Integration of Early Born SST-Expressing

> **NIH NIH R01** · HARVARD MEDICAL SCHOOL · 2022 · $532,008

## Abstract

In the studies supported during the previous funding period we discovered that perinatally deep layer
SST-cINs but not PV-cINs within the barrel cortex receive strong but transient input from the ventrobasal
thalamus. In addition, perturbations to the connectivity of early born deep layer SST-cIN within the
somatosensory cortex have a lasting impact on the subsequent establishment of the feedforward inhibitory
circuits formed between PV cINs and deep layer pyramidal neurons. Our goals within the present proposal
are two-fold. First, we wish to determine whether our previous findings reflect a general principle underlying
the establishment of inhibitory cortical circuitry (Aim 1) by examining the interactions between thalamus,
SST and PV cINs within regions of the cortex that either subserve a similar sensory role in perception (i.e.
visual) or markedly different executive functions (i.e. prefrontal). Moreover, we will leverage our previous
findings to explore the physiological and molecular mechanisms underlying these events in the
somatosensory cortex. Preliminary findings presented here demonstrate a requirement for activity for the
maturation of both SST and PV cINs. In Aim 2, we will explore the hypothesis that the mode of glutamate-
signaling within developing SST cINs controls their connectivity. Specifically, we will test the hypothesis
that ionotropic AMPA-mediated signaling promotes maturation and connectivity of SST cINs, while
mGluR1/5 metabotropic-mediated signaling acts to limit this connectivity. Finally, in Aim 3, we will examine
the molecular changes that occur within SST and PV cINs during the periods when these events occur. We
will also explore the requirement for the NURD-associated transcription factor SatB1, which is activity-
dependent and is required for the maturation of SST and PV cINs both in the establishment of L5/6
inhibitory circuitry.

## Key facts

- **NIH application ID:** 10413849
- **Project number:** 5R01NS081297-10
- **Recipient organization:** HARVARD MEDICAL SCHOOL
- **Principal Investigator:** GORDON J FISHELL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $532,008
- **Award type:** 5
- **Project period:** 2012-09-01 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10413849

## Citation

> US National Institutes of Health, RePORTER application 10413849, The Development and Integration of Early Born SST-Expressing (5R01NS081297-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10413849. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*