The objectives of the Administration and Data Integration Core (Core A) are three-fold: first, the Core will provide administrative support and financial management of the Program Project Grant (PPG); second, the Core will support cross-platform bioinformatics integration and sharing of multi-omic datasets generated by the Cores and Projects; third, the Core will facilitate interactions between the Cores and Projects, as well as between Baylor College of Medicine (BCM) and Washington University School of Medicine (WU), and will also provide overall scientific leadership of the PPG. The Core will be led by Dr. Hui Zheng, Director of the Huffington Center on Aging (HCOA) at BCM, and housed within the HCOA administrative unit. The Core will be co-led by Dr. Cristian Coarfa, Associate Professor of Molecular and Cellular Biology and an expert in integrative analysis and visualization of multi-omic data, who will oversee the bioinformatics and data sharing aspects of the PPG. To ensure effective management and successful execution of the objectives, a Scientific Advisory Board (SAB) will be formed upon notification of award that will be composed of three members with established leadership and scientific expertise in AD, tauopathy, aging, lysosomal biology, proteomics, and metabolomics. The Core will consult with the SAB for overall program management and scientific direction. The Core has also recruited individuals from BCM and WU who will offer support on institutional resources and advice on conflict resolution if needed. The specific aims of the Administration and Data Integration Core are as follows: 1) Provide overall scientific leadership; 2) Provide financial, administrative, and organizational support; 3) Perform multi-omics data analysis and integration and ensure rapid public access to the datasets; 4) Generate a web-based first-in-class Aging- and Tauopathy-associated Lysosomal atlas (ATLas) of the lysosomal proteome and metabolome. Overall, the core is ultimately responsible for the PPG’s success, and will work with NIH and SAB closely to ensure that the team as a whole achieves its milestones and deliverables.