# HEAL Initiative: Antenatal Opioid Exposure Longitudinal Study Consortium

> **NIH NIH PL1** · RESEARCH TRIANGLE INSTITUTE · 2021 · $1,750,001

## Abstract

PROJECT SUMMARY/ABSTRACT
The ACT NOW Outcomes of Babies with Opioid Exposure (OBOE) Study is a longitudinal cohort study
examining neurodevelopmental and behavioral outcomes from birth to 2 years of age among infants with
antenatal opioid exposure compared to controls. The objectives of the ACT NOW OBOE Study are to (1)
determine the impact of antenatal opioid exposure on brain structure and connectivity over the first 2
years of life; (2) define medical, developmental, and behavioral outcomes over the first 2 years of life in
infants exposed to opioids; and (3) explore whether and how the home environment, maternal mental
health, and parenting modify trajectories of brain connectivity and neurodevelopment over the first 2
years of life. In the process of implementing this groundbreaking study, the investigators have identified
significant logistical challenges to study participation faced by families in the target population, including high
levels of food insecurity, substantial mobility in living arrangements, and difficulty with affording
transportation, childcare, and cell phone service. In addition, greater than expected sleeping difficulties have
been encountered among infants, which impacts the performance of the unsedated MRI scans included in
the study. This administrative supplement will provide support to address these challenges, enabling
successful completion of the OBOE study with the targeted sample size. Specifically, the goals of this
administrative supplement to the ACT NOW OBOE study are to (1) address logistical challenges to study
enrollment and participation; and (2) increase study coordinator and MRI scan time to allow for successful
completion of MRI scans of infants throughout the first 2 years of life.

## Key facts

- **NIH application ID:** 10414223
- **Project number:** 3PL1HD101059-01S3
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** CARLA M BANN
- **Activity code:** PL1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,750,001
- **Award type:** 3
- **Project period:** 2019-09-20 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10414223

## Citation

> US National Institutes of Health, RePORTER application 10414223, HEAL Initiative: Antenatal Opioid Exposure Longitudinal Study Consortium (3PL1HD101059-01S3). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10414223. Licensed CC0.

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