# Core 1: Clinicopathological Analysis and Disease Modeling

> **NIH NIH U54** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $266,483

## Abstract

CLINICOPATHOLOGICAL ANALYSIS AND DISEASE MODELING CORE SUMMARY
The primary objective of the Clinicopathological Analysis and Disease Modeling Core (Core B) is to catalyze the
New York University Langone Health (NYULH) Metastasis Research Network Center’s research goals by
providing high-quality, clinically annotated melanoma biospecimens, expertise in human and animal tissue
analyses, and cutting-edge technological resources.
To execute the central scientific strategy of the NYULH Metastasis Research Network Center, Core B will 1)
procure both retrospective and prospective melanoma patient samples needed for cross-validation of murine
data and hypothesis generation for animal model testing, 2) refine cutting-edge imaging technologies for
multispectral immunofluorescence analyses, and 3) provide expertise in the pathological assessment of post-
experimental mouse and human tissues to support the 3 main projects as well as pilot projects. Through a
governance committee, Core B will also provide oversight of biospecimen use. Leveraging the resources of
NYULH Melanoma Program including the recently awarded SPORE, Core B will serve both the NYULH
Metastasis Research Network Center community as well as other Centers of the Network, avoiding duplication
of efforts and maximizing cost-effectiveness and efficiency.
Overall, Core B will provide high quality, annotated melanoma patient biospecimens, cutting-edge technological
resources, and pathological expertise to all Center studies to support the NYULH Metastasis Research Network
Center’s mission to uncover determinants of melanoma metastasis, focused on drivers of early dissemination
and cross-talk with micro-environmental components.

## Key facts

- **NIH application ID:** 10414447
- **Project number:** 1U54CA263001-01A1
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Iman Osman
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $266,483
- **Award type:** 1
- **Project period:** 2022-09-15 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10414447

## Citation

> US National Institutes of Health, RePORTER application 10414447, Core 1: Clinicopathological Analysis and Disease Modeling (1U54CA263001-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10414447. Licensed CC0.

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