We are building a multidisciplinary, thematic center in Aging and Regenerative Medicine. This goal will be advanced by solidifying our cadre of dedicated young scientists to populate this area. It will also benefit from the further development and sustainability of our Genomics, Bioinformatics, and Molecular Imaging Core to support research in the center. The overall objective of the Administrative Core is to provide an efficient and effective organizational structure to ensure good management, integration, and oversight of our COBRE program. This will be achieved by our team of COBRE director, project coordinators, senior mentors, core leaders, other steering committee members, and external advisory committee members. The success of their efforts will be facilitated by our COBRE administrator. These individuals are part of a carefully crafted framework that has as its focus the support and nurturing of our pilot project awardees, as they are guided in their development as independent researchers. This supportive environment is created by ensuring the formative and summative evaluation of the progress of these faculty, and the explicit communication of the expectations placed upon them. Importantly, Phase III will involve a consolidation of research directions that will involve, among others, incentives to incorporate the cutting-edge technologies that our scientific core provides. This, in turn, will enhance the impact of the research and contribute substantially to the sustainability of our center. Thus, we will: (1) Provide skilled personnel for effective fiscal and administrative management of all components of the COBRE program. (2) Ensure that the Pilot Projects Program generates vision and guidance to pilot project investigators in relation to programmatic and career development. (3) Assure the programmatic relevance and sustainability of our Genomics, Bioinformatics, and Molecular Imaging Core through ongoing assessment and evaluation that includes input from stakeholders. (4) Review the scientific accomplishments of the pilot project investigators and the status of the overall center research program under the direction of the Steering Committee, seeking guidance from our External Advisory Committee, to construct effective means to resolve weaknesses. (5) Provide the interface with IDeA program staff for optimal achievement of program development and long-term goals of this COBRE program. To achieve additional cohesion, we are continuing mechanisms such as our seminar series that are designed to attract our investigators, keep them engaged, and to encourage collaborations.