# University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment

> **NIH NIH P30** · UNIVERSITY OF WASHINGTON · 2022 · $1,524,967

## Abstract

ABSTRACT
The theme of the UW Interdisciplinary Center for Exposures, Diseases, Genomics and Environment (EDGE
Center) is "Biochemical and Molecular Mechanisms Underlying Human Variability in Response to
Environmental Exposures". We envision a future in which world-class EHS research informs policy and
practice to significantly reduce the burden of environmentally related diseases. The purpose of this NIEHS
Core Center is to provide the administrative infrastructure and technical support necessary to foster
multidisciplinary collaborations that will extend basic mechanistic studies on environmental health problems to
direct applications in human populations. The EDGE Center will continue to have an emphasis on “gene x
environment” interactions, with an increased emphasis on development and integration of EHS for public
health decision-making. This Center consists of 59 Environmental Health Sciences (EHS) Core investigators
and 35 other investigators involved in Clinical and Translational Sciences (CTS) research at the UW, organized
into 5 disease-based Collaborative Research Teams (CRTs): 1) Environment & Cancer; 2) Developmental &
Reproductive Disorders; 3) Neurodegenerative Diseases; 4) Cardiopulmonary & Metabolic Diseases; and 5)
Hepatic, Renal & Gastrointestinal Diseases.
The outstanding research of UW EHS Core faculty is enhanced by 3 Facility Cores. 1) The Integrative
Environmental Health Sciences Facility Core fosters clinical and translational population-based research and
disaster research response activities. 2) The Genomics, Bioinformatics & Biostatistics and Microphysiological
Systems Core enables Center members to utilize OMICs technologies and provides rigorous analysis of the
data. It also provides access to in vitro systems that mimic complex tissue architecture suitable for
investigating organ-like physiology in the context of toxicological perturbations. 3) The Exposure Assessment,
Biomarkers & Environmental Sensing Core offers state-of-the-art exposure assessment tools and approaches.
In addition, the Center supports exploratory research projects into innovative new ideas related to the theme of
the Center each year through a Pilot Projects Program as well as mini-pilot grants throughout the year. The
Community Engagement Core provides a mechanism to connect Center investigators, community partners,
and other stakeholders in productive bi-directional EHS-focused dialogue and activities.
The resources available through the EDGE Center have assisted members in achieving their fullest potential
as EHS investigators. Center involvement has resulted in numerous publications, research grants, and training
opportunities. Of the 94 current EDGE members, 37 are Principal Investigators on 65 grants that will be active
as of May 31, 2021. The total annual direct costs for these grants are slightly over $36 M, of which
approximately 83% ($30 M) is from NIH. EDGE faculty members are PIs on 11 current NIEHS grants that will
still be active as...

## Key facts

- **NIH application ID:** 10414955
- **Project number:** 5P30ES007033-27
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Joel Daniel Kaufman
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,524,967
- **Award type:** 5
- **Project period:** 1997-06-01 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10414955

## Citation

> US National Institutes of Health, RePORTER application 10414955, University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment (5P30ES007033-27). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10414955. Licensed CC0.

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