# Molecular Basis of B1-Adrenergic Receptor Function

> **NIH NIH R01** · WEILL MEDICAL COLL OF CORNELL UNIV · 2022 · $381,375

## Abstract

Project Description
The long-term objective of this research project is to understand the molecular basis of
the activation of heterotrimeric G-proteins by b1-adrenergic receptor. Hypertension (high
blood pressure) and heart disease are global health concerns. Hypertension can lead to
severe complications and increase the risk of stroke and death. Activation of cardiac b1-
adrenergic receptor leads to increased heart rate and contractility, thus boosting cardiac
output. Mechanistically, following the stimulation of b1-adrenergic receptor, activated G-
protein Gs leads to the stimulation of adenylyl cyclase. In this application, we will focus
on the structural basis of activation of Gs-protein by b1-adrenergic receptors. We will use
biophysical, cellular and pharmacological approaches to gain a deeper understanding of
this activation process. We will investigate the conformational changes of G-proteins
during their activation by b1-adrenergic receptors. We will examine the coupling
specificity of b1-adrenergic receptors and different families of G-proteins. These studies
will advance our understanding of the structure and function of b1-adrenergic receptors,
and aid future development of new-generations of specific inhibitors of b1-adrenergic
receptors with biased signaling and fewer side effects.

## Key facts

- **NIH application ID:** 10414984
- **Project number:** 5R01GM138676-03
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Xin-Yun Huang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $381,375
- **Award type:** 5
- **Project period:** 2020-08-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10414984

## Citation

> US National Institutes of Health, RePORTER application 10414984, Molecular Basis of B1-Adrenergic Receptor Function (5R01GM138676-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10414984. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*