Abstract/Project Summary – METHODOLOGY CORE The Methodology Core for the Center for Perioperative Mental Health will support the iterative adaptation, implementation, and evaluation of a mental health behavioral and pharmacological intervention bundle in real- world care settings. Using a collaborative planning approach, enabled by stakeholder advisory boards (SABs), we propose to address three specific aims: (1) establish an infrastructure to adapt, plan, implement and empirically evaluate an intervention bundle for depression and anxiety among three older adult surgical patient populations and contexts; (2) develop and maintain a comprehensive informatics infrastructure to support seamless data collection, management, and use for the various center projects; and (3) launch an integrated research operations infrastructure to provide training, supervision, expert consultation, and management of projects using mixed methods. Our transdisciplinary team-based approach will allow us to “build and grow the bench” of perioperative mental health research.