# Population Based Research for Alzheimer's Innovation (POP BRAIN)

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $945,335

## Abstract

ABSTRACT
Dr. Yaffe's background and accomplishments make her ideally positioned for the proposed R35 Leadership
Award in ADRD focusing on the AD/ADRD Research Implementation Milestones for population studies,
precision medicine and health disparities. Over the past 20 years, the PI and her team have led a research
program in the epidemiology of ADRD. Within this broad theme, Dr. Yaffe has focused on studies aimed at
identifying risk factors, particularly those that are modifiable (a key component of the exposome), for pre-
clinical cognitive decline and ADRD. Her team has led seminal investigations on physical activity, sleep quality,
cardiovascular risk factors, traumatic brain injury and other key risk factors. In order to achieve the next
platform of research and training in line with the Population Studies Milestone, the team will create an exciting
multidisciplinary program entitled, the UCSF Population Based Research for Alzheimer's Innovation or Pop-
BRAIN. Dr. Yaffe has assembled an outstanding multidisciplinary leadership group to advance ADRD
population health along a highly innovative and impactful roadmap for discovery and next generation of
researchers' development. The R35 mechanism is an ideal platform to enhance Dr. Yaffe's previous line of
investigation in population health but also to pivot to greater emphasis on three themes that are nicely aligned
with Milestone 1.B: 1) a life-course approach to risk factors and novel analytic approaches to studying the life-
course exposome, 2) emphasis on diverse populations and how the exposome and life-course exposures may
differ across groups (by race/ethnicity and sex) and provide insight into risk mechanisms and 3) and the
relatively unexplored inter-relationship of the exposome, social determinants of health and biological pathways
of ADRD. We will conduct these studies using established and novel analytic approaches for investigation in
several cohorts that the investigators lead or have extensive experience with. Implementation of this innovative
line of investigation will highlight new strategies for prevention, underscore the underpinnings for health
disparities in risk of ADRD and offer new insights to the life-course etiology of ADRD. In an equally important
mission, the Pop-BRAIN program will foster the careers of junior investigators from a variety of disciplines
focused on population health for ADRD. This will involve new resources as well as leveraging and harmonizing
existing but disparate programs at UCSF. The program will provide mentoring, didactics, research design and
biostatistics guidance, pilot funding and career development activities across several departments in a unified
hub dedicated to population health. Due to the caliber of her achievements and deep commitment to improving
public health through rigorous scientific inquiry and developing the next generation of investigators, Dr. Yaffe
and her Pop-BRAIN multidisciplinary team of experts are in an ideal position...

## Key facts

- **NIH application ID:** 10415151
- **Project number:** 5R35AG071916-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Kristine Yaffe
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $945,335
- **Award type:** 5
- **Project period:** 2021-07-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10415151

## Citation

> US National Institutes of Health, RePORTER application 10415151, Population Based Research for Alzheimer's Innovation (POP BRAIN) (5R35AG071916-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10415151. Licensed CC0.

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