# Vestibular and Visual Control of Eye Movement

> **NIH NIH R01** · STANFORD UNIVERSITY · 2022 · $628,633

## Abstract

PROJECT SUMMARY
A hallmark of the nervous system is its ability to transform and combine multiple sources of information to guide
behavior, and to tune this signal processing through learning, for more accurate control of behavior. How this
adaptive signal processing is implemented by neural circuits remains largely unknown, due in part to the
presence of feedback loops that mix together and temporally shape neural signals in complex ways. This project
uses an interdisciplinary experimental-computational approach to dissect the signal processing operations
supporting the control of eye movements by vestibular and visual sensory inputs. Rigorous experimental
protocols, computational models, and statistical fitting approaches will be developed to characterize the signal
transformations occurring at multiple sites in the relevant neural circuitry, to disentangle the roles of feedforward
and feedback signals in the control of eye movement behavior. These approaches will be used to analyze how
specific changes in the way vestibular and visual signals are processed by the circuit support adaptive changes
in the amplitude and timing of the eye movement responses to these sensory inputs. By advancing our
understanding of how learning alters the way a circuit computes, this work bridges the key conceptual gap
between neural plasticity at the synaptic level and learning at the behavioral level, and provides a scientific
foundation for the development of improved clinical approaches for promoting recovery or replacement of
vestibular function.

## Key facts

- **NIH application ID:** 10415218
- **Project number:** 5R01DC004154-20
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** MARK S GOLDMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $628,633
- **Award type:** 5
- **Project period:** 1999-09-30 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10415218

## Citation

> US National Institutes of Health, RePORTER application 10415218, Vestibular and Visual Control of Eye Movement (5R01DC004154-20). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10415218. Licensed CC0.

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