The KL2 Mentored Clinical Scholars Program attracts a diverse group of highly talented junior faculty across multiple disciplines from across Yale University (Schools of Medicine, Nursing, Public Health, Faculty of Arts and Sciences, Engineering and Applied Science) who will pursue careers in T1-T4 translational research. This Program has been extremely successful, attracting 151 Scholars who have authored >5200 publications, have been PIs on 258 NIH grants, and have received a total of $557 million in grant funding. Remarkably, 99% of our KL2 Scholars have attained positions in academia, industry or public health conducting, and often with leadership responsibilities for, clinical and translational research. We aim to build on this success by providing Scholars with individualized, competency-based training in translational research that prepares them to contribute to the learning healthcare system, to advance personalized health, and to address health disparities. This preparation includes training in clinical trials, big data, machine learning, bioinformatics, multidisciplinary translational research, team science, implementation science and community-based participatory research. It also introduces them to regulatory issues, bioethics, Good Clinical Practices, and factors that drive rigor, transparency, and replicability. The KL2 promotes the development of relevant competencies among the Scholars by providing: 1) opportunities to work successfully in complex and diverse multidisciplinary research teams, 2) access to mentorship by senior mentors and recent Clinical Scholars, 3) externships in industry, public health and regulatory agencies, and 4) intensive training in grant-writing and in multidisciplinary team science. To oversee these diverse, highly motivated junior investigators, we have an educational leadership team of: 1) three outstanding investigator mentors who work in different areas of translational research, 2) an experienced Diversity Officer, and 3) an expert in evaluating and dynamically reshaping medical education programs. This leadership team has used feedback from prior Scholars and their mentors to add new initiatives to the already successful program. We expanded our logic model to implement social network analyses to track the activities of the Scholars, and we will expand the curriculum to include a new course. That course will mix Scholars and TL-1 trainees who will work in teams as they get formal training and peer mentoring in a variety of areas such as big data/machine learning, diversity and inclusion, and running a research laboratory. With these additions to an already strong curriculum, we believe that the Yale Mentored Clinical Scholars Program will be ideally positioned to train the next generation of leaders in T1-T4 translational research who will transform healthcare in ways that alleviate the burden of disease and improve health in the US and around the world. The Specific Aims of the KL2 are: Aim 1: The...