# High Speed, High Resolution Slide Scanner for Research in Translational Medicine

> **NIH NIH S10** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2022 · $471,886

## Abstract

PROJECT SUMMARY/ABSTRACT
This application is an instrumentation grant from the Analytical Imaging Facility (AIF) at the Albert Einstein
College of Medicine to acquire a fully automated, high-capacity, high-resolution slide scanner that can
accommodate both brightfield and fluorescence imaging. The AIF of the Albert Einstein College of Medicine
supports NIH-funded investigators by giving them access to state-of-the-art microscopy technologies that
enhance collaborative, multidisciplinary research. Acquisition of this instrument will have a high impact on the
biomedical research at Einstein and will expand the scope of NIH-funded projects at Einstein. Several projects
have been identified that will heavily utilize the scanner. These include: the study of the formation of invasion
promoting structures used to systemically disseminate metastatic cancer cells in carcinoma (Condeelis),
correlative Intravital-Histopathologic Imaging to dissect the tumor microenvironment (Entenberg), establishment
and validation of an immunocompromised radiation proctitis mouse model (Guha), studying the prometastatic
effects of neoadjuvant chemotherapy in breast cancer (Karagiannis), investigating the effect of tumor
environment on metastasis (Oktay), the analysis of molecular markers of risk of subsequent invasive breast
cancer in women with ductal carcinoma in situ (Rohan), and the study of hepatocyte heterogeneity with respect
to gene transcription signatures and their zonal distribution within the intact liver in healthy tissue as well as
diseased patient tissue (Singer).There are also additional projects of Minor Users and many users in the Einstein
community are anticipated. All of the projects in this application are in need of high-capacity and high-
reproducibility scanning so that analyses may be applied to larger tissues, covering hundreds of fields of view,
rather than the single fields of view acquired on a standard microscope.

## Key facts

- **NIH application ID:** 10415257
- **Project number:** 1S10OD026852-01A1
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** JOHN S CONDEELIS
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $471,886
- **Award type:** 1
- **Project period:** 2022-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10415257

## Citation

> US National Institutes of Health, RePORTER application 10415257, High Speed, High Resolution Slide Scanner for Research in Translational Medicine (1S10OD026852-01A1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10415257. Licensed CC0.

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