# Systems biology of the tumor immune microenvironment

> **NIH NIH U54** · SLOAN-KETTERING INST CAN RESEARCH · 2021 · $330,912

## Abstract

Systems biology of the tumor immune microenvironment
Project Summary- Research activities proposed for the extension year will exploit syngeneic murine cancer
models established with U54 funding (Projects 1, 3) and recent single cell epigenetic/multiomic and spatial
transcriptomic technologies deployed at our Center (Projects 1, 2, Shared Resource Core), enabling
experimental and computational modeling of tumor-immune interactions with high fidelity to human tumor biology
and at rich single cell and spatial resolution. Below we outline six major activities for the extension year, each
led by a Center investigator and contributing to the original specific aims of our U54 proposal.
1. Modeling T cell, stromal, and cancer cell co-evolution in melanoma (Project 1).
2. Learning gene regulatory programs governing tumor-associated T cell states (Project 1).
3. Spatial analyses of Treg cell-mediated cellular communications in the lung adenocarcinoma
 microenvironment (Project 2).
4. Immune surveillance of metastasis in a syngeneic murine lung adenocarcinoma model (Project 3).
5. Tissue mimetic modeling of the response of metastatic lineages to nutrient gradients (Project 3).
6. Computational integration of single cell RNA and ATAC sequencing data (Shared Resource Core).
.

## Key facts

- **NIH application ID:** 10415307
- **Project number:** 3U54CA209975-05S1
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **Principal Investigator:** Christina S Leslie
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $330,912
- **Award type:** 3
- **Project period:** 2021-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10415307

## Citation

> US National Institutes of Health, RePORTER application 10415307, Systems biology of the tumor immune microenvironment (3U54CA209975-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10415307. Licensed CC0.

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