The major goal of this project is to acquire a Leica CM3050 S Cryostat for a shared use at the University of Rhode Island (URI). The majority of animal users at the URI demand a Cryostat to fulfill the histological needs of diverse research projects. Three NIH-funded users have been identified who are in critical needs of a Cryostat for successful conduct of their projects. Leica CM3050 S Cryostat (configuration 2) is designed to process dedicate tissues and also has a unique safety and user friendly design ideal for shared use. The cryostat will be integrated into the Rhode Island IDeA Network of Biomedical Research Excellence (RI-INBRE) core facility to increase its user access. Leica cryostat is expected to greatly enhance the biomedical research capacities at the URI and also benefit local users from other Institutions. The long-term goal of this project is to establish a histological core to meet the needs of local users.