# Predoctoral Training in the Genetics of Development, Disease and Regeneration

> **NIH NIH T32** · UNIVERSITY OF COLORADO DENVER · 2022 · $240,853

## Abstract

PROJECT SUMMARY / ABSTRACT
The advent of genome editing and induced pluripotent stem cell technologies now provide hope for creating
therapies to treat and cure many developmental diseases. However, incomplete knowledge of the genetic
regulatory mechanisms that guide cell differentiation and function stands as a significant barrier to progress.
Overcoming this barrier will require a workforce with a training foundation that integrates a strong base in
genetics, a deep knowledge of developmental, cellular and molecular mechanisms, and the ability to apply
basic concepts to the translational potential of stem cell biology. The Genetics of Development, Disease, and
Regeneration Training Program seeks to foster a broad foundation of interdisciplinary knowledge and career
development that empowers a diverse population of students to apply their training to the study and treatment
of developmental diseases. To achieve this goal, the GDDR Program is grounded in five training fundamentals:
1) knowledge base, 2) research skills and innovative technology, 3) hypothesis-driven research, 4)
communication skills and 5) professional and career development. The GDDR Program will create a unique
training environment by combining the broad and interdisciplinary research interests of our faculty with a
training plan that integrates genetic principles and mechanisms into the study of development and stem cell
biology. Thirty well-funded and accomplished Training Faculty drawn from 10 basic science and clinical
departments create a highly collaborative and interdisciplinary environment. The breadth of our training
environment will provide trainees with a diverse menu of labs for thesis training, while maintaining a supportive
community and facilitating beneficial interactions between the GDDR Program and other T32-funded programs
at the University of Colorado Anschutz Medical Campus. We will take full advantage of these interactions to
develop courses and training activities that involve multiple programs. Thus we will broaden the exposure of
our trainees to different knowledge, technologies, and career opportunities, and extend the impact of our
training program to benefit a larger population of students and researchers at CU AMC. Based on the quality
and size of our student pool and Training Faculty, we propose to support six trainees per year, which will
permit us to be highly selective while building an interactive group of trainees. Our trainee recruitment plans
are structured to attract highly talented students from diverse backgrounds, thereby contributing to a rich
setting for training and accomplishment.

## Key facts

- **NIH application ID:** 10416012
- **Project number:** 5T32GM141742-02
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Bruce H Appel
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $240,853
- **Award type:** 5
- **Project period:** 2021-07-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10416012

## Citation

> US National Institutes of Health, RePORTER application 10416012, Predoctoral Training in the Genetics of Development, Disease and Regeneration (5T32GM141742-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10416012. Licensed CC0.

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