# Project HOPE: The Pediatric/AYA Omics Project

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $339,999

## Abstract

PROJECT SUMMARY
High grade gliomas (HGG/GBM) across pediatric, adolescent and young adult (AYA), and adult
populations represent a common unmet therapeutic need underpinned by the cellular heterogeneity of
these tumors and its contribution to treatment resistance and residual disease, the ultimate cause of
death. Despite numerous molecular studies across this age spectrum, high grade glioma and
glioblastoma at recurrence remain poorly characterized, despite being the context for most clinical
trials. This project leverages multi-institutional specimen cohorts that addresses the limited availability
of paired longitudinal patient specimens and combines such cohorts with state-of-the-art single-cell
platforms to profile adult and pediatric gliomas through recurrence. Project HOPE team consists of: (1)
Dana Farber Cancer Institute: single cell genomics and analyses (Mariella Filbin); (2) UCSF: single cell
genomics and analyses (Aaron Diaz); (3) Stanford: tissue procurement (Michelle Monje); (4) CHOP:
tissue procurement (Adam Resnick); (5) Data Commons and NCI CDRC and CCDI interoperability and
integration (CHOP: Adam Resnick); (6) Project Coordinator: W. K. Alfred Yung, MD, MD Anderson
Cancer Center. We propose the following aims: Aim 1 - Single cell multi-omic sequencing of cancer
cells in pediatric and AYA high-grade gliomas. Aim 2 - Single nucleus sequencing of the non-immune
microenvironment of pediatric and AYA high-grade gliomas. Aim 3 - Data Commons and Data Sharing.
Overall, by leveraging this unique single-cell multi-omics toolkit for Year 3 of HOPE, and integrating our
findings with project CARE, we will provide novel insights into developmental, genetic, TME, and
epigenetic drivers of cellular states that underlie HGG evolution and resistance to existing therapies
across all age groups.

## Key facts

- **NIH application ID:** 10418576
- **Project number:** 3P30CA082103-22S3
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Alan Ashworth
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $339,999
- **Award type:** 3
- **Project period:** 1999-08-05 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10418576

## Citation

> US National Institutes of Health, RePORTER application 10418576, Project HOPE: The Pediatric/AYA Omics Project (3P30CA082103-22S3). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10418576. Licensed CC0.

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