# Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization

> **NIH NIH U19** · SEATTLE CHILDREN'S HOSPITAL · 2022 · $2,071,529

## Abstract

ABSTRACT (Overall)
Malaria, HIV/AIDS, and Covid are three of the most devastating infectious diseases, impacting millions of people
world-wide. Effective vaccines against the pathogens that cause these diseases (HIV, SARS-CoV-2 and
Plasmodium falciparum) have proven elusive and/or affected by pathogen variation and thus traditional vaccine
approaches are unlikely to succeed in eradicating these diseases. In addition to our limited understanding of the
desired immune responses to confer protection against the pathogens and our limited ability to elicit such
responses, vaccine efficacy is also confounded by the diversity of pathogens, human populations, environmental
exposures, and health status. The projects described herein are designed to support the identification of immune
profiles that correlate with vaccine efficacy and are of potential relevance to protection against HIV-1, SARS
CoV-2 and P. falciparum infection. Beyond the importance of combatting these diseases, the strategies for
profiling immunity in response to infection and vaccination hold promise for garnering fundamental insights into
the complexity of the human immune system. Such insights have the potential to impact strategies for vaccine
development and for producing new therapies for many diseases.

## Key facts

- **NIH application ID:** 10419580
- **Project number:** 2U19AI128914-07
- **Recipient organization:** SEATTLE CHILDREN'S HOSPITAL
- **Principal Investigator:** Margaret Juliana McElrath
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $2,071,529
- **Award type:** 2
- **Project period:** 2017-07-19 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10419580

## Citation

> US National Institutes of Health, RePORTER application 10419580, Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization (2U19AI128914-07). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10419580. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*