# Influence of the College Football Athletes' Cumulative Head Impact Exposure (HIE) on the mTBI incidence and post-mTBI health outcomes

> **NIH NIH R01** · TRUSTEES OF INDIANA UNIVERSITY · 2022 · $370,788

## Abstract

Project Abstract
Sport-related concussion (SRC) is a significant public health problem resulting in over 200,000 annual trips to
the Emergency Department (ED) in the United States with as many as 3.8 million SRCs occurring annually. From
a biomechanical standpoint, the concussion mechanism includes head impact resulting in high magnitude head
rotational accelerations. Human studies measuring the accelerations associated with concussive head impacts
developed injury risk curves that can be extremely useful from the clinical and safety perspectives. However,
recent literature has shown that acceleration magnitudes associated with concussive impacts are extremely
variable and not necessarily distinct from the routinely sustained head impact magnitudes. Mounting evidence
from human studies has demonstrated that repetitive head impact exposure (HIE) may contribute to decreased
SRC tolerance in contact sport athletes.
Studies focused on quantifying the relationship between the HIE and incident concussion have been
underpowered, as there were limited number of concussions occurring during the observation period. We will
utilize the data from the NCAA-DoD Concussion Assessment, Research and Education Consortium (CARE)
Head Impact Measurement Core, the largest and most comprehensive study of SRC and repetitive HIE to date,
and data from Project Head-to-Head 2 (PHTH2), a large-scale study of SRC and HIE in both collegiate and high
school athletes to: (1) determine the association of HIE to SRC occurrence and post-SRC recovery based on
the frequency, number, recency, and severity of head impacts sustained in football activities; and (2) build a
dynamic predictive algorithm of the SRC risk based on the HIE time series data obtained from the HIT System
and other factors, including demographics, concussion history, impact characteristics, and network measures.

## Key facts

- **NIH application ID:** 10420062
- **Project number:** 1R01NS126449-01
- **Recipient organization:** TRUSTEES OF INDIANA UNIVERSITY
- **Principal Investigator:** Jaroslaw Harezlak
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $370,788
- **Award type:** 1
- **Project period:** 2022-03-01 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10420062

## Citation

> US National Institutes of Health, RePORTER application 10420062, Influence of the College Football Athletes' Cumulative Head Impact Exposure (HIE) on the mTBI incidence and post-mTBI health outcomes (1R01NS126449-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10420062. Licensed CC0.

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