# Development and clinical evaluation of the CapScan gastrointestinal sampling device for metabolomics monitoring

> **NIH NIH R21** · ENVIVO BIO INC · 2022 · $221,819

## Abstract

Project Abstract
The goal of this project is to develop the CapScan gastrointestinal (GI) tract sampling capsule, and to utilize
this device to advance our understanding of gastrointestinal disorders. CapScan is a novel ingestible device
with the potential to routinely collect and analyze the microbiota of the GI tract, including the metabolic
transformation of food products by gut microbes. We will develop, bench test and assess the safety,
reproducibility, regional specificity of the CapScan device on healthy human volunteers. We will then utilize the
CapScan device in two additional studies to test the effect of a proton pump inhibitor (PPI) on the microbiome
and metabolome and to measure the regional differences in the GI tract in patients with small intestinal
bacterial overgrowth (SIBO) before and after antibiotic treatment. Given the centrality of the gut to human
health, there will likely be additional uses of the CapScan technology in monitoring a person's health,
eventually making CapScan as routine and informative in the practice of medicine as a blood test is today.

## Key facts

- **NIH application ID:** 10421224
- **Project number:** 1R21CA260665-01A1
- **Recipient organization:** ENVIVO BIO INC
- **Principal Investigator:** Tidhar Dari Shalon
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $221,819
- **Award type:** 1
- **Project period:** 2022-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10421224

## Citation

> US National Institutes of Health, RePORTER application 10421224, Development and clinical evaluation of the CapScan gastrointestinal sampling device for metabolomics monitoring (1R21CA260665-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10421224. Licensed CC0.

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