# PRS Center for Admixed Populations and Health Equity (CAPE)

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $973,761

## Abstract

Project Summary/Abstract
Polygenic risk scores (PRS), that aggregate risk across common variants in the genome, have emerged as a
powerful tool towards implementing genomic medicine. Unfortunately, the vast majority of genomic data from
which current PRS are estimated is coming from European ancestry individuals thus prohibiting the
implementation of PRS for non-European individuals. To address this gap, multiple large-scale genomic
studies are currently performed in non-European individuals. Of particular interest are individuals with recent
ancestry from multiple continental sources such as African Americans and/or Hispanic Americans whose
genomes are a mosaic of segments of various ancestries. Such diversity in genetic ancestry raises unique
challenges in the equitable PRS development as the accuracy and bias of existing PRS varies across genomic
ancestries. Unlike existing paradigm that largely views genetic ancestry as a confounder in PRS studies, we
aim to fully integrate population genetics of the admixture process to yield admixture-PRS that provide
equitable accuracies for all individuals irrespective of genetic ancestries. We will integrate data of over 230,000
admixed individuals across five diverse medical systems including UCLA, Mt Sinai, Colorado to develop,
calibrate and benchmark PRS for admixed individuals.

## Key facts

- **NIH application ID:** 10424501
- **Project number:** 5U01HG011715-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Eimear Elizabeth Kenny
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $973,761
- **Award type:** 5
- **Project period:** 2021-06-08 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10424501

## Citation

> US National Institutes of Health, RePORTER application 10424501, PRS Center for Admixed Populations and Health Equity (CAPE) (5U01HG011715-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10424501. Licensed CC0.

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