# High-Density surface EMG based CMAP scan for motor unit number estimation

> **NIH NIH R21** · MEDICAL COLLEGE OF WISCONSIN · 2020 · $431,700

## Abstract

Project Abstract
 This research aims to develop a novel motor unit number estimation (MUNE) technique that integrates two
recent advances in electrophysiology, i.e. compound muscle action potential (CMAP) scan and high-density
surface electromyography (HDEMG), to provide accurate and reliable estimation of functioning motor units in
the muscle. The proposed technique will be used as a sensitive biomarker for quantifying or tracking motor unit
population in clinical settings or to explore axon excitability and muscle rearrangements in response to
medication, exercises or physical therapies in aging, amyotrophic lateral sclerosis (ALS) and other neurological
disorders.

## Key facts

- **NIH application ID:** 10424869
- **Project number:** 7R21NS113716-02
- **Recipient organization:** MEDICAL COLLEGE OF WISCONSIN
- **Principal Investigator:** Paul E Barkhaus
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $431,700
- **Award type:** 7
- **Project period:** 2021-07-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10424869

## Citation

> US National Institutes of Health, RePORTER application 10424869, High-Density surface EMG based CMAP scan for motor unit number estimation (7R21NS113716-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10424869. Licensed CC0.

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