Project Summary The primary objective of this program is to train predoctoral and postdoctoral research scientists in integrated biobehavioral and sociocultural approaches to the study of mental health and disorder, and comorbidities. The program trains scholars in the development and application of theories and research in behavioral science, integrated with biological and social science, to understand the etiology, progression and treatment of mental disorders and physical disease. The primary program consists of didactic training, intensive supervised research, and a weekly colloquia series. The three pillars of the program are: (1) A coordinated curriculum on biological systems involved in psychopathology and health; (2) Training in state-of-the-art research methods and quantitative techniques; (3) An emphasis on health disparities by ethnicity, race, culture, SES. The program offers advanced quantitative training and mentored research training in translational science including randomized controlled intervention trials, observational/survey research methods, experimental research, and methods of studying immune, neuroendocrine, cardiovascular, neural and genetic processes.Four predoctoral trainees in 2nd through 4th year of studies, and two postdoctoral take required courses and select from electives and research opportunities to create individualized, focused programs of training. The Director and two CoDirectors and 16 affiliated faculty members from the Department of Psychology, the Semel Institute for Neuroscience and Human Behavior, and other units on campus provide the training. This interdisciplinary faculty is composed of a seasoned senior faculty group with a history of collaborating in training and research and selected exceptional midcareer and junior faculty members, who bring a rich array of funded projects, active research labs, interdisciplinary center involvement, and methodological expertise to the program to provide rigorous training in research. The faculty as a whole represents research expertise in specific psychological disorders (e.g., mood disorders, anxiety disorders, substance use disorders, schizophrenia) and physical health (e.g., cancer, cardiovascular disease, maternal/child health, gerontology). Theory and research on pathological processes as well as optimal health and well-being are represented. Cross-cutting content areas include stress processes, emotion regulation/coping, social relationships, and health disparities. Faculty research covers all stages of the lifespan from prenatal/fetal through childhood, adolescence, adults and aging. Finally, core faculty are expert in the development and evaluation of biobehavioral approaches to preventing and treating psychological and physical health problems, and in dissemination and implementation science.