# Functional analysis of SIRPG, a T cell-specific autoimmune gene

> **NIH NIH R21** · BRIGHAM AND WOMEN'S HOSPITAL · 2022 · $268,500

## Abstract

Project Summary
Recent genetic studies have identified numerous genetic variations that are associated with higher risk of
autoimmune diseases. For example, several genetic variations at the SIRPG gene are associated with higher
risk of type 1 diabetes. SIRPG is expressed almost exclusively in T lymphocytes. However, its physiological
function is still unknown due to the lack of a mouse homologue. Nor do we understand how its genetic
variations contribute to the pathogenesis of type 1 diabetes. These important questions will be addressed in
this project with cutting edge genetic engineering technology to ablate SIRPG or reproduce its genetic
variations in human T cells. Data generated from this project will advance our understanding of not only the
function of SIRPG but also the pathogenesis of type 1 diabetes, and eventually lead to novel therapeutic
approaches of autoimmune diseases.

## Key facts

- **NIH application ID:** 10425493
- **Project number:** 1R21AI169191-01
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** I-CHENG HO
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $268,500
- **Award type:** 1
- **Project period:** 2022-02-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10425493

## Citation

> US National Institutes of Health, RePORTER application 10425493, Functional analysis of SIRPG, a T cell-specific autoimmune gene (1R21AI169191-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10425493. Licensed CC0.

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