# Abramson Cancer Center Support Grant

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2021 · $199,375

## Abstract

PROJECT SUMMARY
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-
21-058. The number of cancer survivors living in low- and middle-income countries (LMICs) is expected to grow
rapidly over the next decade driven in part by global advances in early detection and treatment, yet very little is
known about the long-term needs of cancer survivors or delivery of survivorship care in LMICs. This supplement
application will help to fill this critical research gap by quantitatively and qualitatively evaluating care outcomes
and contextual determinants of survivorship care among women diagnosed with cervical cancer in Botswana.
Cervical cancer is one of the leading cancers among women globally with 600,000 new cases and 340,000
deaths annually per 2020 estimates. Cervical cancer is an acquired immunodeficiency syndrome (AIDS)-defining
malignancy, and countries with high rates of human immunodeficiency virus (HIV) have higher incidence of
cervical cancer. Due to high HIV-infection rates and suboptimal screening uptake, most of the burden of cervical
cancer incidence, morbidity, and mortality falls on LMICs particularly in sub-Saharan Africa, with many women
presenting with advanced disease. Botswana, a sub-Saharan African country, has high rates of cervical cancer
(incidence rate of 34.4 per 100,000) and HIV (18.5% prevalence), and a high rate of mortality due to cervical
cancer (20.1 per 100,000) among women. To date, the majority of cancer research in Botswana and other LMICs
has focused on early detection or treatment, with limited research evaluating the long-term physical or
psychosocial outcomes in survivorship or how survivorship care may impact these outcomes. Furthermore, even
less is known regarding which approaches may be most impactful and sustainable to deliver survivorship care
in LMICs. As such, there is a critical need to understand the current state of survivorship in LMICs and to identify
effective strategies to ensure that all women receive optimal survivorship care. The objectives of this project are
to: 1) quantitatively describe a) patterns in post-treatment survivorship care and b) long-term physical and
psychosocial sequelae of cervical cancer using an existing cohort of patients at Princess Marina Hospital in
Gaborone, Botswana; and 2) qualitatively assess contextual determinants (e.g., quality of life, access to
resources, care delivery strategies) shaping patient experiences and adherence to survivorship care. In
combination, these data will be used to develop and/or adapt survivorship care interventions to target the specific
contextual determinants in Botswana and other LMICs. The results of this project will advance scientific
understanding of survivorship care and sequelae in LMICs and how these experiences may or may not differ
from the experiences and needs of cancer survivors in high-income countries. This project will also generate
fundamental evidence needed to ...

## Key facts

- **NIH application ID:** 10425591
- **Project number:** 3P30CA016520-45S7
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Robert H. Vonderheide
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $199,375
- **Award type:** 3
- **Project period:** 2021-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10425591

## Citation

> US National Institutes of Health, RePORTER application 10425591, Abramson Cancer Center Support Grant (3P30CA016520-45S7). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10425591. Licensed CC0.

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